Jason Babyak / AP Bills quarterback J.P. Losman (7) is tackled by the Cardinals' Travis LaBoy during Sunday's game.

Big Ben's big night gave the Pittsburgh Steelers a big boost in the AFC North.

Ben Roethlisberger threw for 309 yards and three touchdowns, helping the visiting Steelers overcome their offensive woes and leading them to a 26-21 victory over the Jacksonville Jaguars on Sunday night.

Pittsburgh (4-1) snapped a four-game losing streak against Jacksonville and stretched its division lead over Baltimore (2-2), which lost to Tennessee earlier in the day.

Roethlisberger finished 26 of 41, rebounding from an interception on his third pass that Rashean Mathis returned 72 yards for a score.

Cardinals 41, Bills 17: The Bills lost their quarterback and, emphatically, their first game of the season.

Second-year quarterback Trent Edwards, a major reason Buffalo was one of three unbeaten teams entering the day, went down with a concussion on a fierce hit from safety Adrian Wilson on the third play of the game. It was the Bills' defense that collapsed after that.

Rookie Tim Hightower had a pair of touchdown runs and Kurt Warner threw to Larry Fitzgerald twice for scores. Warner, who committed six of Arizona's seven turnovers in last week's loss at the Jets, bounced back to go 33 of 42 for 250 yards with no interceptions. The Cardinals (3-2) are 3-0 at home.

Broncos 16, Buccaneers 13: The high-flying Broncos finally discovered a defense, generating a pass rush that sent Brian Griese to the sideline with an injured throwing shoulder.

Jay Cutler guided a patient Denver offense over the visiting Buccaneers (3-2). Brandon Stokley hauled in Cutler's pass in the right flat and followed Brandon Marshall's big block for a 10-yard touchdown and Matt Prater kicked three field goals for Denver.

Giants 44, Seahawks 6: The Giants are this year's New England Patriots — so far.

In a nearly flawless performance, Eli Manning threw two touchdowns, Brandon Jacobs ran for two more and the unbeaten Giants scored on their first five possessions at home.

The win was the eighth straight for the Giants (4-0) dating to last year's playoffs, and it gave the Super Bowl champions their best start since 1990, when they posted a 13-3 record and also won the NFL title.

Falcons 27, Packers 24: Aaron Rodgers played hurt and played hard. But he was upstaged by Matt Ryan and visiting Atlanta.

The Falcons' rookie quarterback turned in another sharp performance, completing 16 of 26 passes for 194 yards, two touchdowns and an interception against the banged-up Packers.

Falcons receiver Roddy White caught eight passes for 132 yards and a touchdown, while Michael Turner ran for 121 yards and a touchdown.

It was the third straight loss for the Packers ().

Panthers 34, Chiefs 0: DeAngelo Williams had 123 yards rushing and scored three touchdowns and host Carolina handed Kansas City its first shutout in nearly six years.

The Panthers (4-1), who have missed the playoffs the past two seasons, are off to their best start since reaching the Super Bowl in the 2003 season.

Bears 34, Lions 7: Kyle Orton set career highs in yards passing, completions and quarterback rating while throwing two touchdowns at Detroit. He was 24 of 34 for 334 yards and had a 121.4 rating, improving to 3-0 against the Lions.

Orton connected with Devin Hester for a touchdown and Charles Tillman intercepted a pass that went off Roy Williams' hands and returned it for a score. Chicago (3-2) broke a first-place tie with the Packers to lead the lackluster NFC North.