Ariel Schalit / AP pool photo President Bush and Israeli President Shimon Peres attend a session of the Knesset in Jerusalem on Thursday.

WASHINGTON — Barack Obama accused President Bush of "a false political attack" Thursday after Bush warned in Israel against appeasing terrorists — early salvos in a general election campaign that's already blazing even as the Democratic front-runner tries to sew up his party's nomination.

The White House denied Bush had targeted Obama, who said the Republican commander in chief's intent was obvious.

In short order, the controversy spilled across the presidential campaign.

John McCain, the Republican nominee-in-waiting, said Obama was showing "naiveté and inexperience and lack of judgment" in his willingness to meet with U.S. foes.

Hillary Rodham Clinton then called Bush's original comments "offensive and outrageous, especially in light of his failures in foreign policy."

As the workday began stateside, Bush gave a speech to Israel's Knesset in which he spoke of the president of Iran, who has called for the destruction of the U.S. ally. Then, the president said: "Some seem to believe that we should negotiate with the terrorists and radicals, as if some ingenious argument will persuade them they have been wrong all along.

"We have heard this foolish delusion before. As Nazi tanks crossed into Poland in 1939, an American senator declared: Lord, if I could only have talked to Hitler, all this might have been avoided.' We have an obligation to call this what it is — the false comfort of appeasement, which has been repeatedly discredited by history," Bush added.

With the president abroad and those seeking to succeed him campaigning at home, the transcontinental tiff signaled the early direction of the general election. Bush seemed to assume the traditional lame-duck presidential role in trying to help the Republican nominee-in-waiting, and Obama tried to maneuver for advantage — and to show strength — while on the cusp of clinching the Democratic nomination.

McCain played his political role as well in tandem with Obama, notable for two White House hopefuls who are campaigning for a bipartisan governing approach free of the often divisive discourse in Washington.

By tradition, partisan politics comes to a halt when a U.S. president is on foreign soil, and Bush's remarks led Obama to quickly cry foul. The first-term Illinois senator responded to the comments as if they were criticism of his position that as president, he would be willing to personally meet with Iran's leaders and those of other regimes the United States has deemed rogue.

"It is sad that President Bush would use a speech to the Knesset on the 60th anniversary of Israel's independence to launch a false political attack," Obama said in a statement his aides distributed. "George Bush knows that I have never supported engagement with terrorists, and the president's extraordinary politicization of foreign policy and the politics of fear do nothing to secure the American people or our stalwart ally Israel.

In turn, White House press secretary Dana Perino denied that the Knesset remark was aimed at Obama. In fact, the language is fairly typical for Bush speeches, and Gordon Johndroe, a national security spokesman for the president, said Bush was referring to "a wide range of people who have talked to or suggested we talk to Hamas, Hezbollah or their state sponsors" over a long period of time.