ANAHEIM — Chicago White Sox manager Ozzie Guillen has developed a reputation for speaking his mind. On Wednesday night, he got credit for changing it.

Guillen shuffled his team's batting order to produce more offense. The trick worked — although it took awhile.

Carlos Quentin, batting third for the first time this season, hit a grand slam off of Scot Shields in the eighth inning to propel the White Sox to a 6-1 victory over the Angels.

The loss overshadowed a strong performance by Angels starter John Lackey, who returned from the disabled list to make his first start of the season. Lackey pitched seven innings, allowing one run and six hits.

"It was nice to be back," Lackey said. "It's been a long road."

The White Sox jumped on Lackey for three hits and a run in the first inning, but the ace of the staff settled down to retire 14 of 15 batters during one stretch. He threw first-pitch strikes to 21 of the 26 batters that he faced.

"I felt pretty good early on," Lackey said. "I was able to throw offspeed stuff for strikes and that was a big key. My fastball is not all the way back. That's probably going to take a few starts but it was a good start."

Quentin drove in five of the White Sox six runs, matching his career high for RBIs in a game. Their other run came on a Nick Swisher home run in the ninth.

"When we don't get runners on base, it's boring," Guillen said, speaking primarily of Tuesday night's shutout loss. "I should get a beer or two beers and just sit and watch the game. Every time we get people on base, there is more enthusiasm and there is more going."

The teams took a 1-1 tie into the eighth, when the White Sox were able to take advantage of a couple of breaks. One was Shields' off-night and the other was a mistake by shortstop Erick Aybar.

Juan Uribe singled to start the eighth inning and Orlando Cabrera followed with a grounder between shortstop and third base. Aybar made a great stop but had no play. Instead of holding the ball, he threw it over the head of first baseman Casey Kotchman, putting runners at second and third.

A.J. Pierzynski was walked intentionally and Quentin hit a 2-0 pitch over the center-field wall for his first career grand slam and league-leading 10th home run.

"You've just got to shake it off," Shields said. "Lackey pitched a pretty good game. For me to get out there, not get anybody out, and give up four runs, it hurts inside."

The Angels' only run came in the fifth inning when Maicer Izturis scored on Mike Napoli's sacrifice fly.

"We haven't been swinging the bats the way we need to for the last 10 days or so," Angels manager Mike Scioscia said. "At some point we've got to start getting a consistent offense and go back to swinging the bats the way we have in the past."